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Leaders Chelsea take on Tottenham Hotspur in a mouth-watering encounter at Stamford Bridge.
The Blues have a 100 per cent record, while Tottenham's went last weekend with a 3-1 defeat to Manchester United.
Chelsea will welcome back Didier Drogba and Jose Bosingwa.
The pair were suspended for the midweek Champions League win over Porto but are available for domestic matches.
Joe Cole (knee), Yuri Zhirkov (knee) and Paulo Ferreira (knee) are all out with coach Carlo Ancelotti saving their return for next week's Carling Cup tie with Queens Park Rangers.
Defender Alex is still struggling with a groin injury.
Goalkeeper Heurelho Gomes stepped up his comeback from a groin injury by playing a friendly against Queens Park Rangers this week.
Full-back Gareth Bale also played following an operation in June to repair a medial meniscal tear on his left knee.
Luka Modric (fibula), Michael Dawson (Achilles) and Jonathan Woodgate (groin) are still sidelined.
Chelsea: Cech, Turnbull, Hilario, Bosingwa, Ivanovic, Terry, Carvalho, A Cole, Ballack, Mikel, Lampard, Anelka, Drogba, Sturridge, Deco, Kalou, Malouda, Essien, Hutchinson, Belletti.
Tottenham: Gomes, Cudicini, Walker, Hutton, Naughton, Corluka, King, Bassong, Assou-Ekotto, Bale, Palacios, Huddlestone, Jenas, Kranjcar, Lennon, Bentley, Giovani, Rose, Pavlyuchenko, Keane, Defoe, Crouch.
